Tretinoin is the most effective of all retinoids. It is used to treat a range of skin issues, from acne and melasma to fine lines and wrinkles, and is so powerful that it is only available with a prescription. Despite the fact that tretinoin is widely used, many individuals are unsure of the crucial dos and don’ts of how and where to apply it. If so, you are not the only one. We’re here to help.

To avoid early minor negative effects and optimize its advantages, it’s crucial to use it properly. This is what you need to know.

Guide In Using Tretinoin

Ensure you correctly introduce tretinoin into your routine before anything else.

Make it Simple

It’s crucial to follow a simple routine when starting any retinoid until your skin has become used to it and you’re certain you’re not feeling any irritation. That includes avoiding potential irritants like salicylic and glycolic acids, as well as scrubs, peels, toners, and serums. Don’t panic, though; with a dermatologist’s permission, you may gradually reintroduce these products!

Apply Carefully

It’s recommended to only apply tretinoin at night, after cleansing your face with a mild cleanser and completely drying it. Apply a tiny layer to your face, keeping your eyes and lips out of the way. Apply a layer of moisturizer once it has thoroughly absorbed into your skin.

Don’t Forget to Use High SPF Sunscreen

It’s necessary to use sunscreen first thing in the morning because retinoids can make us more sensitive to sunlight. Moreover, contact with the sun can reverse some of the skin benefits that your treatment offers! At least SPF 30+, refreshed every few hours, is recommended.

Areas You Can Apply Tretinoin


How near to the eyes should you apply tretinoin? That’s a frequently asked question, especially if you’re taking it to get rid of wrinkles and fine lines. The good news is that, with caution, you can use tretinoin around your eyes. Our dermatology staff advises keeping a gap of at least 5 mm between your treatment and your lower eyelid. Avoid the upper eyelid totally, and avoid rubbing it in too close to the lower lash line.


It’s totally safe to use tretinoin on your cheeks! It is frequently applied here to even out skin texture, fill in sun-damaged areas, and lessen the appearance of hyperpigmentation or melasma. It can improve cell turnover and exfoliate dead skin if you use it regularly, giving you an even, radiant complexion in 8–12 weeks.


We often suggest against using tretinoin treatments on your nose to lower the risk of irritation. It’s usually unnecessary to apply it here, and doing so could result in more cleaning. The only exception to this would be if a dermatology specialist had instructed you to gradually introduce it to this area because of specific hyperpigmentation or acne troubles around your nose.


Once again, no! Applying topical retinoids to the delicate skin on your lips is likely to irritate it; also, you don’t want to accidentally get treatment in your mouth! Tretinoin rarely directly affects the lips while treating skin issues, and unlike specific plumping solutions, it won’t give the appearance of filler by raising collagen. Tretinoin shouldn’t be used on melasma around the top lip without first protecting your lips with an occlusive balm like petroleum jelly. If there is any transfer, wash the area with a gentle cleaner.


The T-zone, which comprises your forehead and chin, two popular locations for acne, is where retinol is frequently utilized to treat a variety of skin issues. Tretinoin’s strong cell-regenerating and exfoliating properties contribute to its remarkable effectiveness in the treatment, and even prevention, of acne. In order to reduce fine wrinkles and improve skin elasticity, we also use it in anti-ageing therapies.

Body, Chest and Neck

Although it may be tempting, you should only apply your retinoid cream on your neck, chest, or body if instructed to do so by a dermatology professional. This skin is distinct from the skin on your face and is more sensitive. We recommend an in-person consultation to prescribe a treatment plan for these issues instead of using our formulations, which are not intended for them. Inform every new dermatologist you see whether you’re currently using a Tretinoin Creams formula for your face so they know you’re not using two products at once!

Managing The Side Effects

It’s still possible that you will encounter side effects after using tretinoin, even if you follow our instructions. Redness, dryness, flaking, irritation, and mild burning sensations are just a few typical early side effects. There is no need to be concerned about these; they will go away on their own.

But side effects, no matter how little they are, can be unpleasant. We advise using tretinoin every other night at first, until your skin adapts, to help relieve them. As a buffer, you can also try dabbing on a thin layer of moisturizer before your treatment.

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